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Blood pressure

Posted: Sun Aug 13, 2017 3:40 pm
by Nicke
For many years my Bp was too high. It doesnt matter how much medicin I take, maximum doses, it stay far too high. I was and still taken 100 mg Losartan and 10 mg Lerkanidipin.

Some people are immun to BT-medicin. I am one of the unlucky bastards Then, in the end my new doctor gave me Spironolactone as recently is approved to high BT for CKD-patients. In two days my BT went down from 95/145 to 70/130.

Now I take 50 mg Spironolactone on top and feel ok. If you take too much and you are a male, you got nice bitchtits growing :roll: , so take it easy with it. With my cystkidney-super-sumo-belly I do not go around topless anyway. :roll:

Re: Blood pressure

Posted: Mon Aug 14, 2017 8:51 am
by freddyy
That is unfortunate, as Losartan also has some other benefits for protecting the kidneys as I understood it from my nephrologist (other than just lowering blood pressure). And also low risks of side effects.

Luckily I'm doing fine with just 2x 12.5mg Losartan daily. BP around 120-130 over 60-70. Doesn't seem to increase as kidney function declines, so I guess the "BP regulation part" of the kidney is still working for me.

However I had a few rounds of prednisone treatments for my ulcerative colitis which raises blood pressure temporary, up to about 145 systolic. It steadily drops with every week of tapering. Not worried about though - actually my creatinine values have consistently gone down and I've gained back 1-2% eGFR every time I've started a prednisone treatment. :D

Re: Blood pressure

Posted: Mon Aug 14, 2017 6:18 pm
by Nicke
There is a interesting study: (Lancet Sept 2015) "Spironolactone versus placebo, bisoprolol, and doxazosin
to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2)".

The conclusion of PATHWAY-2 became spironolactone Is the most effective supplementary treatment
In resistant hypertension And that finding supports the hypothesis that Retention of salt plays an important role in
Hard-treatment high blood pressure.

Another interesting study about the "arteriovenous fistula hypothesis" described in "Arteriovenous fistula as a nephroprotective intervention in advanced CKD: scientific discovery and explanation, and the evaluation of interventions"

In a series of 123 patients, with at least two estimated glomerular filtration rate (eGFR) determinations for 2 years before and up to 2 years after functioning fistula creation. Before the intervention, the rate of GFR loss was 5.9 mL/min/year, which dramatically reduced to 0.5 mL/min/year following the same intervention.

So, for some of us with AF, the kidney dialysis will be on hold for several months or more! :D

For "Freddy" Check this link in Swedish page 4: ... 1_2016.pdf

Re: Blood pressure + Vitamin K2

Posted: Tue Aug 15, 2017 6:31 am
by freddyy
Wow, hadn't even considered the possibility that just having an AV fistula could be of benefit (before using it). I was offered many times now by my nurse to have the surgery done, but so far I've managed to postpone it. My goal is to tough it out until my planned transplant on October 12th. And contrary to what both my nephrologists as well as my nurses guessed, I've held on from around 8% eGFR for almost a year now. Even up to 10% by now.
(I will still get a catheter shoved into my heart week before op for pre-transplant dialysis and filtering of ABO antibodies though...)

I had totally missed that scripture "Nefromedia". It has some very interesting articles, thanks for the tip!

Also you had some interesting facts about vitamin K2 in another thread. Seems like something that would be very sensible to add to my diet (especially since I take quite a lot of D3). I'm thinking with my CKD as well as colitis there is a slim chance my body converts enough K1 to K2. And it sure would be nice to reduce risk of cardiovascular events since that is our main cause of mortality.

Do you have any specific tips for brands or shops where you purchase K2? (If you do take it yourself?) Seems expensive in Sweden, but very cheap in UK through Amazon. Question is if those brands are trustworthy or not.

Maybe we have UK residents here who have any experience or tips regarding purchases of supplements through amazon? Can we trust the quality, are some brands better, are there some to avoid?

Re: Blood pressure

Posted: Tue Aug 15, 2017 10:31 am
by Nicke

I have already answered Freddyy in a personal mail, but for information for the forum residens, I will give som info.

There are running 152 studies about Vitamin K1 and K2 in the world . Some of them completed. ... rch=Search

A handfull large university/hospital studies are about vascular calcification and K1/K2 in CKD-patients.

The Vitamin K1 supplimention for CDK-patients is in som studies in fase III. Meaning when and if the results will be available and good. It will be a treatment for CDK-patients in a few years from now.

Vitamin K1 and K2 must be taken with vitamin D. They work together. It is essential.
There are lot of information in the internet about K1/K2 and CDK.

To Activate MGP (Matrix-Gla Protein you need K2-mk7. For bonestrenght take K1. MGP push circulated calcium in your blood back to the bones so it not calcificate your heart and venes. The best and cheapest in Sweden anyway, is Natto (K2-mk7) from Nattopharma. It is produced in Japan.