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New HLA-desensitization treatment

Posted: Thu Aug 03, 2017 6:44 pm
by freddyy
Just read a press release today with some good news which might be of interest to some people here. :D

A medical company (Hansa) has been developing a new drug (IdeS) based on an bacterial enzyme which targets the HLA antibodies in a transplant recipient. Initital tests with 25 highly sensitized people seem to have shown great success in 24 of the patients after 6 month followup. Not so many people, and not so long time yet, but sounds promising at least!

Seems like it could be great news for people needing transplants beyond their first after gaining more HLA antibodies.

Reuters wrote a piece on it over at ... SKBN1AI2A5 if you are interested. :)

Re: New HLA-desensitization treatment

Posted: Sun Aug 13, 2017 11:22 am
by Nicke
I am a kidney patient in renal stage 5 and now waiting to get on the transplantation list. I am lucky not have problem with ant-antibodies as mention in your mess. Besides,

The Hansa Medical breakthrough is the best and biggest news since Ciklosporin introduced 1982 !
I do not understand why nobody here talk about it. This will allow 30 percent more kidney transplantations and probably better transplant results for many others when this will be standard protocol.
Hopefull this treatment will be available in just a year or two as FDA have stress this approval as VERY important.

Another thing:
I thank the power there is EVERYDAY I am not a citizen in "the greatest country in the world" and they "Obamacare" joke.

In Sweden we have 5 year graft survival 94-96 percent. It is the best result ww, and all medical treatment is for FREE all your life.
The only bill you pay is 12 euro/day in hospital and 180 euro for medicin/year. No matter the cost. The rest is for free.

So when I heard the annual cost for supressive medicin in US for the patients are 25000 USD I stand in awe. Horrible!

Re: New HLA-desensitization treatment

Posted: Mon Aug 14, 2017 8:16 am
by freddyy
It is indeed very exciting research. I am also excited about the possibilities of CRISPR-Cas9. Just a few days ago several news sites reported about eliminating some retroviruses as well as some other materials in the organs of pigs which have been a show-stopper for pig->human transplants. With specially engineered pigs we could perhaps solve the organ shortage in short order. They had equal hopes to solve remaining issues of rejection using same techniques.

You are absolutely right, we should be thankful to live in a civilization where healthcare is viewed upon as a basic right and not as a commodity for the wealthy.

The medicines for suppression are pretty expensive here (In Sweden) too, even if we pay it through taxes. I did some research about Betalacept and found a study from TLV where they compare cost effectiveness to Tacrolimus and Cyclosporine. Cyclosporine is about 5000 euro/year, Tacrolimus slightly more expensive at around 6000 euro/year, and Betalacept much more expensive at 14000 euro/year (and was deemed not to be worth the cost). I think another common suppressive agent (MMF) is also pretty expensive. Prednisone is dirt cheap though.
All this is of course just a fraction of what dialysis costs. Getting people transplanted saves quite a lot of money in the end.

But yeah, even adding all that up we are still far off from the 25k USD that Americans pay. I guess single-payer system helps with negotiating prices down quite a lot!